SrasV1, Main, Exploration, bibRecord, 002943

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

Identifieur interne : 002943 ( Main/Exploration ); précédent : 002942; suivant : 002944

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

Auteurs : Mark A. Clementz [États-Unis] ; ZHONGBIN CHEN [République populaire de Chine] ; Bridget S. Banach [États-Unis] ; YANHUA WANG [République populaire de Chine] ; LI SUN [République populaire de Chine] ; Kiira Ratia [États-Unis] ; Yahira M. Baez-Santos [États-Unis] ; JIE WANG [États-Unis] ; Jun Takayama [États-Unis] ; Arun K. Ghost [États-Unis] ; KUI LI [États-Unis] ; Andrew D. Mesecar [États-Unis] ; Susan C. Baker [États-Unis]

Source :

Journal of virology [ 0022-538X ] ; 2010.

RBID : Pascal:10-0294182

Descripteurs français

Pascal (Inist)
- Coronavirus, Interféron.

English descriptors

KwdEn :
- Coronavirus, Interferon.

Abstract

Coronaviruses encode multifunctional proteins that are critical for viral replication and for blocking the innate immune response to viral infection. One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN). Here we characterized the DUB and IFN antagonism activities of the PLP domains of human coronavirus NL63 and severe acute respiratory syndrome (SARS) coronavirus to determine if DUB activity mediates interferon antagonism. We found that NL63 PLP2 deconjugated ubiquitin (Ub) and the Ub-line molecule ISG15 from cellular substrates and processed both lysine-48- and lysine-63- linked polyubiquitin chains. This PLP2 DUB activity was dependent on an intact catalytic cysteine residue. We demonstrated that in contrast to PLP2 DUB activity, PLP2-mediated interferon antagonism did not require enzymatic activity. Furthermore, addition of an inhibitor that blocks coronavirus protease/DUB activity did not abrogate interferon antagonism. These results indicated that a component of coronavirus PLP-mediated interferon antagonism was independent of protease and DUB activity. Overall, these results demonstrate the multifunctional nature of the coronavirus PLP domain as a viral protease, DUB, and IFN antagonist and suggest that these independent activities may provide multiple targets for antiviral therapies.

Affiliations:

Links toward previous steps (curation, corpus...)

to stream PascalFrancis, to step Corpus: 000155
to stream PascalFrancis, to step Curation: 000833
to stream PascalFrancis, to step Checkpoint: 000154
to stream Main, to step Merge: 002986
to stream Main, to step Curation: 002943

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases</title>
<author><name sortKey="Clementz, Mark A" sort="Clementz, Mark A" uniqKey="Clementz M" first="Mark A." last="Clementz">Mark A. Clementz</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhongbin Chen" sort="Zhongbin Chen" uniqKey="Zhongbin Chen" last="Zhongbin Chen">ZHONGBIN CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Banach, Bridget S" sort="Banach, Bridget S" uniqKey="Banach B" first="Bridget S." last="Banach">Bridget S. Banach</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanhua Wang" sort="Yanhua Wang" uniqKey="Yanhua Wang" last="Yanhua Wang">YANHUA WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li Sun" sort="Li Sun" uniqKey="Li Sun" last="Li Sun">LI SUN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baez Santos, Yahira M" sort="Baez Santos, Yahira M" uniqKey="Baez Santos Y" first="Yahira M." last="Baez-Santos">Yahira M. Baez-Santos</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jie Wang" sort="Jie Wang" uniqKey="Jie Wang" last="Jie Wang">JIE WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Molecular Sciences, University of Tennessee Health Science Center</s1>
<s2>Memphis, Tennessee 38163</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis, Tennessee 38163</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takayama, Jun" sort="Takayama, Jun" uniqKey="Takayama J" first="Jun" last="Takayama">Jun Takayama</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>West Lafayette, Indiana 47907</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghost, Arun K" sort="Ghost, Arun K" uniqKey="Ghost A" first="Arun K." last="Ghost">Arun K. Ghost</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>West Lafayette, Indiana 47907</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kui Li" sort="Kui Li" uniqKey="Kui Li" last="Kui Li">KUI LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Molecular Sciences, University of Tennessee Health Science Center</s1>
<s2>Memphis, Tennessee 38163</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis, Tennessee 38163</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">10-0294182</idno>
<date when="2010">2010</date>
<idno type="stanalyst">PASCAL 10-0294182 INIST</idno>
<idno type="RBID">Pascal:10-0294182</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000155</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000833</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000154</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000154</idno>
<idno type="wicri:doubleKey">0022-538X:2010:Clementz M:deubiquitinating:and:interferon</idno>
<idno type="wicri:Area/Main/Merge">002986</idno>
<idno type="wicri:Area/Main/Curation">002943</idno>
<idno type="wicri:Area/Main/Exploration">002943</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases</title>
<author><name sortKey="Clementz, Mark A" sort="Clementz, Mark A" uniqKey="Clementz M" first="Mark A." last="Clementz">Mark A. Clementz</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zhongbin Chen" sort="Zhongbin Chen" uniqKey="Zhongbin Chen" last="Zhongbin Chen">ZHONGBIN CHEN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Banach, Bridget S" sort="Banach, Bridget S" uniqKey="Banach B" first="Bridget S." last="Banach">Bridget S. Banach</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Yanhua Wang" sort="Yanhua Wang" uniqKey="Yanhua Wang" last="Yanhua Wang">YANHUA WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li Sun" sort="Li Sun" uniqKey="Li Sun" last="Li Sun">LI SUN</name>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>Division of Infection and Immunity, Department of Electromagnetic and Laser Biology, Beijing Institute of Radiation Medicine</s1>
<s2>Beijing 100850</s2>
<s3>CHN</s3>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
</inist:fA14>
<country>République populaire de Chine</country>
<placeName><settlement type="city">Pékin</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baez Santos, Yahira M" sort="Baez Santos, Yahira M" uniqKey="Baez Santos Y" first="Yahira M." last="Baez-Santos">Yahira M. Baez-Santos</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Jie Wang" sort="Jie Wang" uniqKey="Jie Wang" last="Jie Wang">JIE WANG</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Molecular Sciences, University of Tennessee Health Science Center</s1>
<s2>Memphis, Tennessee 38163</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis, Tennessee 38163</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Takayama, Jun" sort="Takayama, Jun" uniqKey="Takayama J" first="Jun" last="Takayama">Jun Takayama</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>West Lafayette, Indiana 47907</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Ghost, Arun K" sort="Ghost, Arun K" uniqKey="Ghost A" first="Arun K." last="Ghost">Arun K. Ghost</name>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Chemistry, Purdue University</s1>
<s2>West Lafayette, Indiana 47907</s2>
<s3>USA</s3>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>West Lafayette, Indiana 47907</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Kui Li" sort="Kui Li" uniqKey="Kui Li" last="Kui Li">KUI LI</name>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Molecular Sciences, University of Tennessee Health Science Center</s1>
<s2>Memphis, Tennessee 38163</s2>
<s3>USA</s3>
<sZ>8 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Memphis, Tennessee 38163</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicinal Chemistry and Pharmacognosy, University of Illinois</s1>
<s2>Chicago, Illinois 60607</s2>
<s3>USA</s3>
<sZ>6 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Chicago, Illinois 60607</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Department of Microbiology and Immunology, Loyola University Chicago Stritch School of Medicine</s1>
<s2>Maywood, Illinois 60153</s2>
<s3>USA</s3>
<sZ>1 aut.</sZ>
<sZ>3 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>États-Unis</country>
<wicri:noRegion>Maywood, Illinois 60153</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
<imprint><date when="2010">2010</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">Journal of virology</title>
<title level="j" type="abbreviated">J. virol.</title>
<idno type="ISSN">0022-538X</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Coronavirus</term>
<term>Interferon</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Coronavirus</term>
<term>Interféron</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Coronaviruses encode multifunctional proteins that are critical for viral replication and for blocking the innate immune response to viral infection. One such multifunctional domain is the coronavirus papain-like protease (PLP), which processes the viral replicase polyprotein, has deubiquitinating (DUB) activity, and antagonizes the induction of type I interferon (IFN). Here we characterized the DUB and IFN antagonism activities of the PLP domains of human coronavirus NL63 and severe acute respiratory syndrome (SARS) coronavirus to determine if DUB activity mediates interferon antagonism. We found that NL63 PLP2 deconjugated ubiquitin (Ub) and the Ub-line molecule ISG15 from cellular substrates and processed both lysine-48- and lysine-63- linked polyubiquitin chains. This PLP2 DUB activity was dependent on an intact catalytic cysteine residue. We demonstrated that in contrast to PLP2 DUB activity, PLP2-mediated interferon antagonism did not require enzymatic activity. Furthermore, addition of an inhibitor that blocks coronavirus protease/DUB activity did not abrogate interferon antagonism. These results indicated that a component of coronavirus PLP-mediated interferon antagonism was independent of protease and DUB activity. Overall, these results demonstrate the multifunctional nature of the coronavirus PLP domain as a viral protease, DUB, and IFN antagonist and suggest that these independent activities may provide multiple targets for antiviral therapies.</div>
</front>
</TEI>
<affiliations><list><country><li>République populaire de Chine</li>
<li>États-Unis</li>
</country>
<settlement><li>Pékin</li>
</settlement>
</list>
<tree><country name="États-Unis"><noRegion><name sortKey="Clementz, Mark A" sort="Clementz, Mark A" uniqKey="Clementz M" first="Mark A." last="Clementz">Mark A. Clementz</name>
</noRegion>
<name sortKey="Baez Santos, Yahira M" sort="Baez Santos, Yahira M" uniqKey="Baez Santos Y" first="Yahira M." last="Baez-Santos">Yahira M. Baez-Santos</name>
<name sortKey="Baker, Susan C" sort="Baker, Susan C" uniqKey="Baker S" first="Susan C." last="Baker">Susan C. Baker</name>
<name sortKey="Banach, Bridget S" sort="Banach, Bridget S" uniqKey="Banach B" first="Bridget S." last="Banach">Bridget S. Banach</name>
<name sortKey="Ghost, Arun K" sort="Ghost, Arun K" uniqKey="Ghost A" first="Arun K." last="Ghost">Arun K. Ghost</name>
<name sortKey="Jie Wang" sort="Jie Wang" uniqKey="Jie Wang" last="Jie Wang">JIE WANG</name>
<name sortKey="Kui Li" sort="Kui Li" uniqKey="Kui Li" last="Kui Li">KUI LI</name>
<name sortKey="Mesecar, Andrew D" sort="Mesecar, Andrew D" uniqKey="Mesecar A" first="Andrew D." last="Mesecar">Andrew D. Mesecar</name>
<name sortKey="Ratia, Kiira" sort="Ratia, Kiira" uniqKey="Ratia K" first="Kiira" last="Ratia">Kiira Ratia</name>
<name sortKey="Takayama, Jun" sort="Takayama, Jun" uniqKey="Takayama J" first="Jun" last="Takayama">Jun Takayama</name>
</country>
<country name="République populaire de Chine"><noRegion><name sortKey="Zhongbin Chen" sort="Zhongbin Chen" uniqKey="Zhongbin Chen" last="Zhongbin Chen">ZHONGBIN CHEN</name>
</noRegion>
<name sortKey="Li Sun" sort="Li Sun" uniqKey="Li Sun" last="Li Sun">LI SUN</name>
<name sortKey="Yanhua Wang" sort="Yanhua Wang" uniqKey="Yanhua Wang" last="Yanhua Wang">YANHUA WANG</name>
</country>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/SrasV1/Data/Main/Exploration

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002943 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 002943 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    SrasV1
   |flux=    Main
   |étape=   Exploration
   |type=    RBID
   |clé=     Pascal:10-0294182
   |texte=   Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases
}}

This area was generated with Dilib version V0.6.33.
Data generation: Tue Apr 28 14:49:16 2020. Site generation: Sat Mar 27 22:06:49 2021

	Serveur d'exploration SRAS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration SRAS

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

Deubiquitinating and Interferon Antagonism Activities of Coronavirus Papain-Like Proteases

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri